Mast cells are hypersensitive immune cells that release histamine and other inflammatory mediatorsoften in response to oxidative stress, environmental toxins, and immune imbalance. Many patients with MCAS have low levels of glutathione. Did you know one single mast cell can release chemicals that affect your skin, gut, heart, brain, and immune system all at once? That's why MCAS can feel so overwhelming, the 3 controversial amino acids in Histamine Intolerance and MCAS What is glutathione and why must we protect patient access to it? Supplements and MCAS Mast Cell Action